United States securities and exchange commission logo November 15, 2022 Peter Cancelmo General Counsel and Secretary OMEROS CORP 201 Elliott Avenue West Seattle, WA 98119 Re: OMEROS CORP Registration Statement on Form S-3 Filed November 9, 2022 File No. 333-268269 Dear Peter Cancelmo: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact Lauren Hamill at 303-844-1008 with any questions. Sincerely, Division of Corporation Finance Office of Life Sciences cc: Matthew Franker